Why Use The Expensive Analog Insulin And Not The Cheaper Regular Insulin?
Regular insulin (the generic version) exists in a complex form called a hexamer. This structure slows down how quickly it’s absorbed into the bloodstream after injection. Because of this delay, Regular insulin needs to be taken 20 to 30 minutes before a meal—something many people find hard to follow. It stays active in the body for 6 to 7 hours, which increases the risk of low blood sugar (hypoglycemia).
In contrast, rapid-acting insulin analogs like Lispro (Humalog, Admelog, Lyumjev), Aspart (Novolog, Fiasp), and Glulisine (Apidra) are in a simpler form called monomers. These are absorbed into the bloodstream much faster, so they start working quickly. Their effects typically last 3 to 5 hours, which helps lower blood sugar after meals with a reduced risk of lows (Hypoglycemia).
Some newer analog insulins, like Lyumjev and Fiasp, contain added ingredients to help them absorb even faster. This means they can be taken with or even right after a meal.
Fiasp is a type of Aspart insulin that includes Vitamin B3 (niacinamide). Niacinamide widens (dilates) blood vessels, allowing the insulin to enter the bloodstream more quickly.
Lyumjev is a Lispro insulin that includes small amounts of treprostinil, a substance that increases blood flow at the injection site through local widening (dilatation) of blood vessels.
These added ingredients make Fiasp and Lyumjev act even faster than other rapid-acting insulins, with a lower chance of causing low blood sugar.
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