Why Use The Expensive Analog Insulin And Not The Cheaper Regular Insulin?
Regular insulin (Generic) is in a complex (hexamer) state; this delays the absorption of insulin from the injection site into the bloodstream, resulting in the slow onset of action. For this reason, Regular insulin needs to be taken 20 to 30 minutes before a meal (most patients find this difficult to comply with). Regular insulin’s effects last for 6 to 7 hours, resulting in more frequent low blood sugars.
Whereas the newer analog insulins, such as Lispro (Humalog, Admelog, Lyumjey)), Aspart (Novolog, Fiasp), Glulisine (Apidra), are in a simpler form (monomers). Hence these are rapidly absorbed into the bloodstream, making the onset of action much quicker. Also, their effect lasts for much shorter periods, usually 3-5 hours. For these reasons, these insulin analogs generally give better post-meal blood glucose, with a lower incidence of low blood sugars.
Lyumjev and Fiasp are analog insulins with additional substances (excipients) to enhance their absorption. Hence these are absorbed very rapidly can be taken with or soon after meals. They have a lower risk of hypoglycemia than the analog insulin without the incipients.
Fiasp is Aspart insulin with the addition of Vitamin B3 (niacinamide). Niacinamide causes dilatation of blood vessels, which leads to faster absorption of the insulin.
Lyumjev is Lispro insulin with microdoses of treprostinil are used as an excipient to increase blood flow at the site of injection through localized vasodilation
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